Niacin — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19CYP2D6CYP2C9CYTOCHROMENFE2L2RATTUSMUSHOMOHTR2ASNCATRHRHCAR2HCAR1HCAR3
14 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)5 targets overlapping
Biological oxidations3 targets overlapping
Drug ADME3 targets overlapping
Uncovered Pathway Targets
226 totalADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2+216 more…
Genes present in the top pathway union that Niacin does not directly modulate.
Top Stack Candidates
Aripiprazole
score 6,886.473#1 gap-filler · 34 targets covered · evidence score 52.0
ADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1AVPR1A+22
Astemizole Antihistamine drug now withdrawn from
score 6,692.191#2 gap-filler · 33 targets covered · evidence score 48.7
ADRA1AADRA2AADRA2CADRB2APLNRAVPR1ACHRM1CHRM2CHRM3DRD1DRD2DRD3+21
961 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.