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BiohacksAI

Evidence-Based Biohacking

Patent Pending
BiohacksAI/Mechanism Hypothesis/Nicorandil

Nicorandil — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2C9MUSCHRM5CHRM4KCNJ8KCNJ11

7 known targets mapped from PubChem bioassay data

Pathway Context

Biological oxidations2 targets overlapping
Drug ADME2 targets overlapping

Uncovered Pathway Targets

230 total
AADACAHCYAHRALDH1A1ALDH2AOC1ARNTCBR3CES1CES2+220 more…

Genes present in the top pathway union that Nicorandil does not directly modulate.

Top Stack Candidates

Aripiprazole

#1 gap-filler · 36 targets covered · evidence score 52.0

score 7,143.225
CYP2D6CYP3A7MAOAABCB1ADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1+24
Astemizole Antihistamine drug now withdrawn from

#2 gap-filler · 35 targets covered · evidence score 48.7

score 6,932.649
CYP19A1CYP2D6CYP2J2CYP3A4ABCB1ADRA1AADRA2AADRA2CADRB2APLNRAVPR1ACHRM1+23

987 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.