obeticholic acid [Supplementary Concept] — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
RATTUSMUSADRA1ANR1H4GPX4PHOSPHOLIPIDGPBAR1EPHX2BILE
9 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)2 targets overlapping
Fatty acid metabolism2 targets overlapping
Biosynthesis of DHA-derived SPMs2 targets overlapping
Uncovered Pathway Targets
183 totalADORA2BADORA3ADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3+173 more…
Genes present in the top pathway union that obeticholic acid [Supplementary Concept] does not directly modulate.
Top Stack Candidates
Astemizole Antihistamine drug now withdrawn from
score 6,899.332#1 gap-filler · 35 targets covered · evidence score 48.7
ADRA2AADRA2CADRB2APLNRAVPR1ACHRM1CHRM2CHRM3DRD1DRD2DRD3DRD4+23
Fluoxetine
score 6,723.675#2 gap-filler · 24 targets covered · evidence score 73.4
ADRA1BADRA1DADRA2AADRA2BADRA2CCCKBRCHRM3CHRM5CNR1DRD1DRD2EDNRA+12
936 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.