BiohacksAI/Mechanism Hypothesis/Oxymetazoline

Oxymetazoline — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2D6CYTOCHROMETDP1CYP3A4CHRM15-HYDROXYTRYPTAMINEADRA1AHTR2AHTR1AADRA2AHTR2BADRA2CADRA2BHTR2CPTGS2ALPHA-2AADRA1BADRA1DALPHA-2BALPHA-1DALPHA-1AALPHA-2CALPHA-1BHTR1BMUSCARINICHTR1DNISCH

27 known targets mapped from PubChem bioassay data

Pathway Context

Class A/1 (Rhodopsin-like receptors)11 targets overlapping

Amine ligand-binding receptors11 targets overlapping

G alpha (q) signalling events7 targets overlapping

Uncovered Pathway Targets

158 total

ADORA2BADORA3ADRB1ADRB2ADRB3AGTR1AGTR2APLNRAPPAVPR1A+148 more…

Genes present in the top pathway union that Oxymetazoline does not directly modulate.

Top Stack Candidates

Astemizole Antihistamine drug now withdrawn from

#1 gap-filler · 23 targets covered · evidence score 48.7

score 5,158.113

ADRB2APLNRAVPR1ACHRM2CHRM3DRD1DRD2DRD3DRD4GALR2GHSRHRH1+11

Aripiprazole

#2 gap-filler · 23 targets covered · evidence score 52.0

score 5,130.847

ADORA3ADRB1ADRB2ADRB3AGTR1AVPR1ACHRM2DRD1DRD2DRD3DRD4DRD5+11

633 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.