BiohacksAI/Mechanism Hypothesis/Oxymetholone

Oxymetholone — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

ARCYP2C9NR1I2ESR1CYTOCHROMETDP1THRBESRRACYP3A4CYP3A7NFE2L2SYKTYROSINE-PROTEINGLI3PGRNSD2RORCHISTONE-LYSINERARAEUCHROMATICHTR2AESR2ALDEHYDEPTGS2ANDROGENADORA3CASP3HSPB1CASP7GPR32RXFP1

31 known targets mapped from PubChem bioassay data

Pathway Context

Nuclear Receptor transcription pathway7 targets overlapping

SUMOylation5 targets overlapping

SUMO E3 ligases SUMOylate target proteins5 targets overlapping

Uncovered Pathway Targets

123 total

ESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1NR1D2NR1H2+113 more…

Genes present in the top pathway union that Oxymetholone does not directly modulate.

Top Stack Candidates

Progesterone

#1 gap-filler · 17 targets covered · evidence score 50.6

score 4,446.542

ESRRGHNF4AHNF4GNR1H2NR1H4NR2F1NR3C1NR3C2NR4A2NR5A1NR5A2RARB+5

Quercetin

#2 gap-filler · 18 targets covered · evidence score 43.4

score 3,769.58

NR3C1PPARGRXRAAURKBBLMNFKB2RELATOP1TOP2ATP53CREB1HSP90AA1+6

548 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.