pentamidine — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2D6SYKTYROSINE-PROTEINNSD2MUSHISTONE-LYSINEKCNH25-HYDROXYTRYPTAMINEHOMODRD1ADRA2ASLC6A3ACHESLC6A4MU-TYPESLC6A2SODIUM-DEPENDENTCHRM2ALPHA-2AALPHA-1AMAOAALPHA-1BMUSCARINICGRIN1GRIN2AGRIN2BPRMT1SLC22A2GRIN2CGRIN2DHRH3GRIN3AGRIN3BAMINESLC47A1PLGSLC22A3PROTHROMBINSLC47A2TRANSMEMBRANEAOC1SAT1ST14PTP4A3PTP4A1PTP4A2S100B
47 known targets mapped from PubChem bioassay data
Pathway Context
Neuronal System9 targets overlapping
Transmission across Chemical Synapses8 targets overlapping
SLC-mediated transmembrane transport6 targets overlapping
Uncovered Pathway Targets
322 totalABATABCC8ABCC9ADCY9ALDH2ALDH5A1BCHECACNA1BCACNA2D1CACNA2D2+312 more…
Genes present in the top pathway union that pentamidine does not directly modulate.
Top Stack Candidates
Aripiprazole
score 7,448.677#1 gap-filler · 34 targets covered · evidence score 52.0
HTR3AHTR3BHTR3CHTR3DHTR3EMDM2ADORA3ADRA1AADRA1BADRA1DADRA2BADRA2C+22
Ondansetron
score 6,777.269#2 gap-filler · 24 targets covered · evidence score 56.7
CHRNA4GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRG2GABRG3+12
819 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.