Phenformin — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
SYKTYROSINE-PROTEINADRA2AHTR2BGRIN1SLC22A1
6 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)2 targets overlapping
Hemostasis2 targets overlapping
Neuronal System2 targets overlapping
Uncovered Pathway Targets
376 totalADORA2BADORA3ADRA1AADRA1BADRA1DADRA2BADRA2CADRB1ADRB2ADRB3+366 more…
Genes present in the top pathway union that Phenformin does not directly modulate.
Top Stack Candidates
Aripiprazole
score 9,093.885#1 gap-filler · 42 targets covered · evidence score 52.0
ADORA3ADRA1AADRA1BADRA1DADRA2BADRA2CADRB1ADRB2ADRB3AGTR1AVPR1ACHRM1+30
Astemizole Antihistamine drug now withdrawn from
score 8,365.53#2 gap-filler · 40 targets covered · evidence score 48.7
ADRA1AADRA2CADRB2APLNRAVPR1ACHRM1CHRM2CHRM3DRD1DRD2DRD3DRD4+28
900 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.