Phentolamine — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19CYP2D6CYTOCHROMECYP3A7RATTUSKCNH25-HYDROXYTRYPTAMINEADRA1AHOMOESR2HTR1AADRA2AHTR2BADRA2CNTMT1ADRA2BSLC6A4KAPPA-TYPEALPHA-2AADRA1BADRA1DALPHA-2BALPHA-1DALPHA-1AALPHA-2CALPHA-1BSCN2ASIGMAR1SCN3ASCN1AHTR1EHSF1NISCH
33 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)9 targets overlapping
Amine ligand-binding receptors9 targets overlapping
Adrenoceptors6 targets overlapping
Uncovered Pathway Targets
218 totalADORA2BADORA3ADRB1ADRB2ADRB3AGTR1AGTR2APLNRAPPAVPR1A+208 more…
Genes present in the top pathway union that Phentolamine does not directly modulate.
Top Stack Candidates
Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on
score 9,649.042#1 gap-filler · 33 targets covered · evidence score 44.3
ADRB1ADRB2ADRB3DRD2DRD3DRD4TSHRCREB1GRK2TAS2R1TAS2R10TAS2R13+21
Aripiprazole
score 5,623.813#2 gap-filler · 26 targets covered · evidence score 52.0
ADORA3ADRB1ADRB2ADRB3AGTR1AVPR1ACHRM1CHRM2DRD1DRD2DRD3DRD4+14
708 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.