Pregnenolone — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
ARNR1I2ESR1THRBESRRACYP3A7NFE2L2SYKTYROSINE-PROTEINPGRRORCNR3C1ESR2IFNGSHBGSERPINA6
16 known targets mapped from PubChem bioassay data
Pathway Context
Nuclear Receptor transcription pathway7 targets overlapping
SUMOylation5 targets overlapping
SUMO E3 ligases SUMOylate target proteins5 targets overlapping
Uncovered Pathway Targets
124 totalESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1NR1D2NR1H2+114 more…
Genes present in the top pathway union that Pregnenolone does not directly modulate.
Top Stack Candidates
Bortezomib
score 12,335.364#1 gap-filler · 42 targets covered · evidence score 44.2
PPARDRARAHDAC1HDAC2MITFNFKB2PARP1RELATP53ADRM1HDAC3PSMA1+30
Progesterone
score 4,576.975#2 gap-filler · 18 targets covered · evidence score 50.6
ESRRGHNF4AHNF4GNR1H2NR1H4NR2F1NR3C2NR4A2NR5A1NR5A2RARARARB+6
521 more candidates · full stack optimisation locked
Enter your API token to unlock the complete analysis.
BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.