Promethazine — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19CYP2D6ARCYTOCHROMECYP1A2THRBCYP3A7GLI3PGRNSD2RORCHISTONE-LYSINEKCNH2RARAEUCHROMATICCHRM1DRD35-HYDROXYTRYPTAMINEADRA1AHTR2ADRD2ESR2DRD1HTR1AADRA2AHTR2BADRA2CJUNADRA2BATXN2SLC6A4MU-TYPESLC6A2HTR2CKAPPA-TYPESODIUM-DEPENDENTCHRM2HRH1ALPHA-2ACHRM3ALPHA-2BHRH2ALPHA-1DHTTALPHA-1AALPHA-2CDRD4ALPHA-1BMUSCARINICCBX1SCN2AGPR32HISTAMINESCN3ASCN1AGPT2SIGMAPRNP
58 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)17 targets overlapping
Amine ligand-binding receptors17 targets overlapping
G alpha (q) signalling events7 targets overlapping
Uncovered Pathway Targets
263 totalADORA2BADORA3ADRA1BADRA1DADRB1ADRB2ADRB3AGTR1AGTR2APLNR+253 more…
Genes present in the top pathway union that Promethazine does not directly modulate.
Top Stack Candidates
Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on
score 9,558.5#1 gap-filler · 32 targets covered · evidence score 44.3
ADRA1BADRA1DADRB1ADRB2ADRB3TSHRCREB1GRK2TAS2R1TAS2R10TAS2R13TAS2R14+20
Clotrimazole
score 4,795.411#2 gap-filler · 21 targets covered · evidence score 48.8
ADORA3ADRB2ADRB3AVPR2CCR4CXCR1GPR55NPSR1RXFP1TRHRTSHRMAPK1+9
841 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.