BiohacksAI/Mechanism Hypothesis/Promethazine

Promethazine — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6ARNR1I2ESR1CYP1A2THRBESRRAGLI3PGRRORCKCNH2RARAEUCHROMATICCHRM1DRD3HTR2ADRD2ESR2CYP19A1JUNNTMT1ACHENR1H4SMAD3SMAD2CHRM5CHRM4CASP3PPARDBAZ2BCASP7KCNMB1KCNMB2GFERNFKB1GPR151MPHOSPH8GNRHRKCNMB4TXNRD1KCNMA1TRHRTRPC6TRPC4

45 known targets mapped from PubChem bioassay data

Pathway Context

Nuclear Receptor transcription pathway9 targets overlapping

Class A/1 (Rhodopsin-like receptors)8 targets overlapping

SUMOylation6 targets overlapping

Uncovered Pathway Targets

208 total

ESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1NR1D2NR1H2+198 more…

Genes present in the top pathway union that Promethazine does not directly modulate.

Top Stack Candidates

Astemizole Antihistamine drug now withdrawn from

#1 gap-filler · 31 targets covered · evidence score 48.7

score 6,441.968

PPARGADRA1AADRA2AADRA2CADRB2APLNRAVPR1ACHRM2CHRM3DRD1DRD4GALR2+19

Aripiprazole

#2 gap-filler · 29 targets covered · evidence score 52.0

score 6,136.834

ADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1AVPR1A+17

812 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.