Propantheline — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2D6ARCYP1A2CHAINNUCLEARABCB1CHRM1PPARGCHRM5CHRM4RGS4TRPC6
12 known targets mapped from PubChem bioassay data
Pathway Context
G alpha (q) signalling events4 targets overlapping
Class A/1 (Rhodopsin-like receptors)3 targets overlapping
Amine ligand-binding receptors3 targets overlapping
Uncovered Pathway Targets
219 totalADRA1AADRA1BADRA1DAGTR1APPAVPR1AAVPR1BBDKRB1BDKRB2BTK+209 more…
Genes present in the top pathway union that Propantheline does not directly modulate.
Top Stack Candidates
Aripiprazole
score 7,149.38#1 gap-filler · 35 targets covered · evidence score 52.0
ADRA1AADRA1BADRA1DAGTR1AVPR1AGNA15HRH1HTR2AHTR2BHTR2CMLNRTACR1+23
Astemizole Antihistamine drug now withdrawn from
score 7,032.36#2 gap-filler · 35 targets covered · evidence score 48.7
ADRA1AAVPR1ACHRM3GHSRGNA15HRH1HTR2AHTR2BHTR2CMLNROXTRTACR1+23
930 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.