BiohacksAI/Mechanism Hypothesis/Propranolol

Propranolol — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6CYP2C9CYTOCHROMETDP1RATTUSMUSKCNH2EUCHROMATICDRD35-HYDROXYTRYPTAMINEHTR1AADRB2HTR2BSLC6A4HTR2CSODIUM-DEPENDENTADRB1HTR1BADRB3SCN5ABETA-1SIGMABETA-3BETA-2SLC10A1NR2E1

27 known targets mapped from PubChem bioassay data

Pathway Context

Class A/1 (Rhodopsin-like receptors)7 targets overlapping

Amine ligand-binding receptors7 targets overlapping

Biological oxidations3 targets overlapping

Uncovered Pathway Targets

224 total

ADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CAGTR1AGTR2+214 more…

Genes present in the top pathway union that Propranolol does not directly modulate.

Top Stack Candidates

Fluoxetine

#1 gap-filler · 21 targets covered · evidence score 73.4

score 6,076.72

ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CCCKBRCHRM3CHRM5CNR1DRD1DRD2+9

Astemizole Antihistamine drug now withdrawn from

#2 gap-filler · 29 targets covered · evidence score 48.7

score 6,032.471

ADRA1AADRA2AADRA2CAPLNRAVPR1ACHRM1CHRM2CHRM3DRD1DRD2DRD4GALR2+17

944 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.