BiohacksAI/Mechanism Hypothesis/protriptyline

protriptyline — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2D6CHAINKCNH2CHRM1DRD35-HYDROXYTRYPTAMINEADRA1ADRD2DRD1HTR2BADRA2BPMP22SLC6A4SLC6A2HTR2CKAPPA-TYPEMAPTSODIUM-DEPENDENTCHRM2HRH1CHRM3NFKB1SCN2ATHPOSCN3ASCN1A

26 known targets mapped from PubChem bioassay data

Pathway Context

Class A/1 (Rhodopsin-like receptors)11 targets overlapping

Amine ligand-binding receptors11 targets overlapping

G alpha (q) signalling events6 targets overlapping

Uncovered Pathway Targets

220 total

ADORA2BADORA3ADRA1BADRA1DADRA2AADRA2CADRB1ADRB2ADRB3AGTR1+210 more…

Genes present in the top pathway union that protriptyline does not directly modulate.

Top Stack Candidates

Astemizole Antihistamine drug now withdrawn from

#1 gap-filler · 24 targets covered · evidence score 48.7

score 5,496.038

ADRA2AADRA2CADRB2APLNRAVPR1ADRD4GALR2GHSRHRH2HRH4HTR1AHTR2A+12

Aripiprazole

#2 gap-filler · 24 targets covered · evidence score 52.0

score 5,371.839

ADORA3ADRA1BADRA1DADRA2AADRA2CADRB1ADRB2ADRB3AGTR1AVPR1ADRD4DRD5+12

661 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.