Psilocybin — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
MUS5-HYDROXYTRYPTAMINEHTR2AHTR2BHTR2C
5 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)3 targets overlapping
G alpha (q) signalling events3 targets overlapping
Amine ligand-binding receptors3 targets overlapping
Uncovered Pathway Targets
166 totalADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2+156 more…
Genes present in the top pathway union that Psilocybin does not directly modulate.
Top Stack Candidates
Aripiprazole
score 6,551.723#1 gap-filler · 31 targets covered · evidence score 52.0
ADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1AVPR1A+19
Astemizole Antihistamine drug now withdrawn from
score 5,928.077#2 gap-filler · 28 targets covered · evidence score 48.7
ADRA1AADRA2AADRA2CADRB2APLNRAVPR1ACHRM1CHRM2CHRM3DRD1DRD2DRD3+16
674 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.