BiohacksAI/Mechanism Hypothesis/Quinidine

Quinidine — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6CYP2C9NR1I2ESR1CYTOCHROMETDP1THRBESRRACYP3A4CYP3A7MUSABCB1KCNH2DRD35-HYDROXYTRYPTAMINEADRA1AHTR2ADRD2AHRIFNGHTR2BADRA2BSLC6A3SLC6A4MU-TYPEKAPPA-TYPESCN2ACACNA1CSCN3ASCN1ASCN5ASLC22A1VOLTAGE-GATEDSLCO1A1BCHECACNA1DKCNK10CACNA1FCACNA1SPOTASSIUMABCB1BSLC29A4KCNT2KCNH1KCNA5CYP2D2KCNT1KCND2KCNA7KCNA4KCNH5KCNK16KCNK5KCNK6KCNU1MULTIDRUG

57 known targets mapped from PubChem bioassay data

Pathway Context

Neuronal System10 targets overlapping

Muscle contraction10 targets overlapping

Cardiac conduction10 targets overlapping

Uncovered Pathway Targets

251 total

ABATABCC8ABCC9ACHEADCY9ALDH2ALDH5A1CACNA1BCACNA2D1CACNA2D2+241 more…

Genes present in the top pathway union that Quinidine does not directly modulate.

Top Stack Candidates

Ondansetron

#1 gap-filler · 18 targets covered · evidence score 56.7

score 5,365.054

ACHECHRNA4GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRG2+6

Colchicine

#2 gap-filler · 22 targets covered · evidence score 42.1

score 5,191.559

GLRA1GLRA2MDM2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBA8TUBAL3TUBB1+10

717 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.