BiohacksAI/Mechanism Hypothesis/Riluzole

Riluzole — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19ARNR1I2ESR1CYP1A2THRBESRRACYP3A4PGRNSD2HISTONE-LYSINENUCLEARTP53NR3C1RARAHTR2AAHRHTR1AIFNGATAD5SLC6A2SODIUM-DEPENDENTHDAC9SCN2ANLRP3TARDBPRAB9ANPC1SMARCA4KCNK2GRIA2KCNN1KCNN2KCNN3KCND3KCNN4KCNK4GLYCOGENCACNG2RYANODINE

40 known targets mapped from PubChem bioassay data

Pathway Context

SUMOylation7 targets overlapping

SUMO E3 ligases SUMOylate target proteins7 targets overlapping

Nuclear Receptor transcription pathway7 targets overlapping

Uncovered Pathway Targets

205 total

AURKAAURKBBIRC5BLMBRCA1CREBBPCTBP1DNMT1DNMT3BEIF2AK2+195 more…

Genes present in the top pathway union that Riluzole does not directly modulate.

Top Stack Candidates

Nocodazole Nocodazole is

#1 gap-filler · 26 targets covered · evidence score 42.9

score 5,738.023

BRCA1CREBBPMDM2MITFNR1H4PARP1PPARGVDRNR0B1CREB1TUBA1ATUBA1B+14

Colchicine

#2 gap-filler · 25 targets covered · evidence score 42.1

score 5,737.081

BRCA1CREBBPMDM2NR1H4VDRNR0B1GLRA1GLRA2TUBA1ATUBA1BTUBA1CTUBA3C+13

657 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.