Sildenafil Citrate — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
ARCYP2C9NR1I2CYTOCHROMECYP3A4CYP3A7GLI3PGRRATTUSNSD2HISTONE-LYSINERARACA1CA5BCA6PDE5A
16 known targets mapped from PubChem bioassay data
Pathway Context
SUMOylation4 targets overlapping
SUMO E3 ligases SUMOylate target proteins4 targets overlapping
Nuclear Receptor transcription pathway4 targets overlapping
Uncovered Pathway Targets
126 totalAURKAAURKBBIRC5BLMBRCA1CREBBPCTBP1DNMT1DNMT3BEIF2AK2+116 more…
Genes present in the top pathway union that Sildenafil Citrate does not directly modulate.
Top Stack Candidates
Progesterone
score 4,906.716#1 gap-filler · 22 targets covered · evidence score 50.6
ESR1NR1H2NR1H4NR3C1NR3C2NR4A2NR5A1NR5A2RORARXRATP53ESR2+10
Quercetin
score 3,760.092#2 gap-filler · 22 targets covered · evidence score 43.4
AURKBBLMESR1NFKB2NR3C1PPARGRELARXRATOP1TOP2ATP53ESRRA+10
804 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.