Simvastatin — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19CYP2D6ARCYP2C9NR1I2ESR1CYTOCHROMETDP1THRBESRRACYP3A4CYP3A7NFE2L2SYKTYROSINE-PROTEINGLI3PGRNSD2RORCMUSHISTONE-LYSINENR3C1ABCB15-HYDROXYTRYPTAMINEHOMODRD2ESR2DRD1CYP19A1HTR2BPTGS1SLC6A3NR1H4SLC6A2MDM2MDM4ABCB11IDH1ADORA3KCNMB1KCNMB2ADRB3TBXA2RSLCO1B1TARDBPPLK1LRRC26NR1I3CYP2C8NR4A2HMGCRICMT
52 known targets mapped from PubChem bioassay data
Pathway Context
Nuclear Receptor transcription pathway10 targets overlapping
Biological oxidations8 targets overlapping
Phase I - Functionalization of compounds8 targets overlapping
Uncovered Pathway Targets
115 totalESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1NR1D2NR1H2+105 more…
Genes present in the top pathway union that Simvastatin does not directly modulate.
Top Stack Candidates
Progesterone
score 3,859.489#1 gap-filler · 15 targets covered · evidence score 50.6
ESRRGHNF4AHNF4GNR1H2NR2F1NR3C2NR5A1NR5A2RARARARBRARGRORA+3
Luteolin 5,7,3',4'-tetrahydroxy-flavone,
score 3,262.846#2 gap-filler · 16 targets covered · evidence score 40.6
NR1H2NR1H3PPARGCBR3CYP1A1CYP1A2CYP1B1GSTO1MAOAAURKBBLMNFKB2+4
593 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.