BiohacksAI/Mechanism Hypothesis/Spironolactone

Spironolactone — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6ARNR1I2ESR1CYTOCHROMETDP1CYP1A2THRBESRRANFE2L2CHAINGLI3PGRRATTUSRORCNUCLEARTP53NR3C1RARAESR2CYP19A1PPARGNR1H4MDM2IL1BMDM4ANDROGENGLUCOCORTICOIDPPARDESTROGENNR3C2

32 known targets mapped from PubChem bioassay data

Pathway Context

Nuclear Receptor transcription pathway12 targets overlapping

SUMOylation11 targets overlapping

SUMO E3 ligases SUMOylate target proteins11 targets overlapping

Uncovered Pathway Targets

115 total

ESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1NR1D2NR1H2+105 more…

Genes present in the top pathway union that Spironolactone does not directly modulate.

Top Stack Candidates

Progesterone

#1 gap-filler · 13 targets covered · evidence score 50.6

score 3,604.229

ESRRGHNF4AHNF4GNR1H2NR2F1NR4A2NR5A1NR5A2RARBRARGRORARXRA+1

Luteolin 5,7,3',4'-tetrahydroxy-flavone,

#2 gap-filler · 16 targets covered · evidence score 40.6

score 3,212.433

NR1H2NR1H3AURKBBLMNFKB2PARP1RELATOP1WRNCBR3CYP1A1CYP1B1+4

640 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.