Sulfisoxazole — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
ARESR1ESRRACHRM1RXRATHYROIDEDNRA
7 known targets mapped from PubChem bioassay data
Pathway Context
Nuclear Receptor transcription pathway4 targets overlapping
SUMOylation3 targets overlapping
SUMO E3 ligases SUMOylate target proteins3 targets overlapping
Uncovered Pathway Targets
127 totalESR2ESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1NR1D2+117 more…
Genes present in the top pathway union that Sulfisoxazole does not directly modulate.
Top Stack Candidates
Bortezomib
score 12,676.26#1 gap-filler · 45 targets covered · evidence score 44.2
ESR2NR1I2PGRPPARDRARAHDAC1HDAC2MITFNFKB2PARP1RELATP53+33
Progesterone
score 4,914.59#2 gap-filler · 21 targets covered · evidence score 50.6
ESR2ESRRGHNF4AHNF4GNR1H2NR1H4NR1I2NR2F1NR3C1NR3C2NR4A2NR5A1+9
606 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.