Sulpiride — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19CYP2D6CYP2C9CYTOCHROMERORCKCNH2DRD3DRD2DRD1ADRA2ANTMT1RXRACA1ALPHA-2ACA2CA7CA12CA5ACA5BCA9DRD4CA6CAR15DRD5CARBONIC
25 known targets mapped from PubChem bioassay data
Pathway Context
Reversible hydration of carbon dioxide8 targets overlapping
Class A/1 (Rhodopsin-like receptors)6 targets overlapping
Amine ligand-binding receptors6 targets overlapping
Uncovered Pathway Targets
197 totalCA13CA14CA3CA4ADORA2BADORA3ADRA1AADRA1BADRA1DADRA2B+187 more…
Genes present in the top pathway union that Sulpiride does not directly modulate.
Top Stack Candidates
Fluoxetine
score 6,142.557#1 gap-filler · 21 targets covered · evidence score 73.4
ADRA1AADRA1BADRA1DADRA2BADRA2CCCKBRCHRM3CHRM5CNR1EDNRAHRH1HRH2+9
Astemizole Antihistamine drug now withdrawn from
score 5,898.698#2 gap-filler · 28 targets covered · evidence score 48.7
ADRA1AADRA2CADRB2APLNRAVPR1ACHRM1CHRM2CHRM3GALR2GHSRHRH1HRH2+16
868 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.