Sumatriptan — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2D6RATTUS5-HYDROXYTRYPTAMINEHTR2AHTR1AHTR2CHTR7HTR6HTR1BHTR1DHTR5AHTR1FHTR1EHTR3ASLC47A1HTR3BPOU2F1AQP4
18 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)6 targets overlapping
Amine ligand-binding receptors6 targets overlapping
Serotonin receptors6 targets overlapping
Uncovered Pathway Targets
293 totalADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2+283 more…
Genes present in the top pathway union that Sumatriptan does not directly modulate.
Top Stack Candidates
Aripiprazole
score 8,194.217#1 gap-filler · 38 targets covered · evidence score 52.0
ADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1AVPR1A+26
Astemizole Antihistamine drug now withdrawn from
score 6,952.218#2 gap-filler · 33 targets covered · evidence score 48.7
ADRA1AADRA2AADRA2CADRB2APLNRAVPR1ACHRM1CHRM2CHRM3DRD1DRD2DRD3+21
817 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.