BiohacksAI/Mechanism Hypothesis/Testosterone

Testosterone — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6ARNR1I2ESR1CYTOCHROMETDP1THRBESRRACYP3A4NFE2L2CHAINGLI3PGRRATTUSRORCNR3C1ABCB1RARAHOMOESR2CYP19A1PMP22RXRAANDROGENCREB1GLUCOCORTICOIDSHBGCACNA1CSIGMAR1SERPINA6ESTROGENSLCO1A1AKR1C4SRD5A1SRD5A2

36 known targets mapped from PubChem bioassay data

Pathway Context

Nuclear Receptor transcription pathway9 targets overlapping

SUMOylation7 targets overlapping

SUMO E3 ligases SUMOylate target proteins7 targets overlapping

Uncovered Pathway Targets

121 total

ESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1NR1D2NR1H2+111 more…

Genes present in the top pathway union that Testosterone does not directly modulate.

Top Stack Candidates

Progesterone

#1 gap-filler · 15 targets covered · evidence score 50.6

score 4,117.665

ESRRGHNF4AHNF4GNR1H2NR1H4NR2F1NR3C2NR4A2NR5A1NR5A2RARBRARG+3

Quercetin

#2 gap-filler · 16 targets covered · evidence score 43.4

score 3,495.211

PPARGAURKBBLMNFKB2RELATOP1TOP2ATP53HSP90AA1HSP90AB1HSPB1IGF1R+4

462 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.