Thioridazine — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19CYP2D6ARCYP2C9NR1I2ESR1TDP1CYP1A2THRBESRRACHAINGLI3RORCTP53KCNH2RARAEUCHROMATICCHRM1DRD3HTR2ADRD2DRD1CYP19A1IFNGPPARGADRB2TSHRJUNNTMT1ATXN2ACHEMDM2MDM4IDH1CHRM5CHRM4CASP3BAZ2BCASP7KCNMB1KCNMB2GFERPPP1R15AMPHOSPH8MAP4K2KCNMB4NLRP3KCNMA1NPSR1TRHRKCNQ1APAF1ANO1KCNJ2TRPC6TRPC4KCNQ2RAD52NCOA2PTBP1OXTRMLLT3CASP1UBE2NPREPLARNTTACC3NLRP1NPBWR1MMP14MCHR1
71 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)14 targets overlapping
SUMOylation8 targets overlapping
SUMO E3 ligases SUMOylate target proteins8 targets overlapping
Uncovered Pathway Targets
328 totalADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB3+318 more…
Genes present in the top pathway union that Thioridazine does not directly modulate.
Top Stack Candidates
Aripiprazole
score 8,198.951#1 gap-filler · 36 targets covered · evidence score 52.0
ADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB3AGTR1AVPR1ACHRM2+24
Astemizole Antihistamine drug now withdrawn from
score 6,784.717#2 gap-filler · 31 targets covered · evidence score 48.7
ADRA1AADRA2AADRA2CAPLNRAVPR1ACHRM2CHRM3DRD4GALR2GHSRHRH1HRH2+19
878 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.