BiohacksAI/Mechanism Hypothesis/Thyroxine

Thyroxine — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C9NR1I2THRBCYP3A4CYP3A7NFE2L2SYKTYROSINE-PROTEINCHAINPGRNR3C1ABCB1AHRPPARGNR1H4RXRANNMTPNMTGAMTGNMTHNMTCATECHOLKCNMB1KCNMB2SLCO1B1PDE4DKCNMB4PLA2G7TTRPIP4K2APPP1CAUGT1A1ATG4BSLCO1A5SLCO1A2SLCO4C1SLCO1A4RXRBRXRGSLC6A1THRASLCO1C1SLC16A2

43 known targets mapped from PubChem bioassay data

Pathway Context

Nuclear Receptor transcription pathway9 targets overlapping

Biological oxidations8 targets overlapping

SUMOylation7 targets overlapping

Uncovered Pathway Targets

118 total

ARESR1ESR2ESRRAESRRBESRRGHNF4AHNF4GNCOR1NCOR2+108 more…

Genes present in the top pathway union that Thyroxine does not directly modulate.

Top Stack Candidates

Progesterone

#1 gap-filler · 21 targets covered · evidence score 50.6

score 4,644.58

ARESR1ESR2ESRRAESRRGHNF4AHNF4GNR1H2NR2F1NR3C2NR4A2NR5A1+9

Luteolin 5,7,3',4'-tetrahydroxy-flavone,

#2 gap-filler · 17 targets covered · evidence score 40.6

score 3,332.798

NR1H2NR1H3CBR3CYP19A1CYP1A1CYP1A2CYP1B1CYP2C19GSTO1MAOAAURKBBLM+5

783 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.