Tilorone — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
ESR1TDP1ESRRANFE2L2SYKTYROSINE-PROTEINNSD2HISTONE-LYSINENUCLEARTP53CHRM1VDRATXN2ACHEPMP22CFTRNR1H4CHRM2CHRM5CHRM4CREB1YAP1CHRM3GPR151CHRNA7
25 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)5 targets overlapping
Amine ligand-binding receptors5 targets overlapping
Muscarinic acetylcholine receptors5 targets overlapping
Uncovered Pathway Targets
195 totalADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2+185 more…
Genes present in the top pathway union that Tilorone does not directly modulate.
Top Stack Candidates
Astemizole Antihistamine drug now withdrawn from
score 6,723.091#1 gap-filler · 34 targets covered · evidence score 48.7
ADRA1AADRA2AADRA2CADRB2APLNRAVPR1ADRD1DRD2DRD3DRD4GALR2GHSR+22
Aripiprazole
score 6,626.785#2 gap-filler · 33 targets covered · evidence score 52.0
ADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1AVPR1A+21
882 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.