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BiohacksAI

Evidence-Based Biohacking

Patent Pending
BiohacksAI/Mechanism Hypothesis/Troglitazone

Troglitazone — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6ARCYP2C9NR1I2ESR1CYTOCHROMETDP1THRBESRRACYP3A4CYP3A7NFE2L2GLI3PGRRORCTP53NR3C1RARACHRM1DRD35-HYDROXYTRYPTAMINEADRA1AHOMOHTR2AESR2DRD1CYP19A1HTR1APPARGHTR2BTSHRPTGS1SLC6A3PMP22NR1H4SLC6A2PTGS2ANDROGENABCB11ADORA3HSPB1ABCC2RAPGEF3PDE4DCACNA1CADENOSINECGMP-INHIBITEDMAOBPPARARXFP1PDE4ACARBONICALOX15BAMINEMITOGEN-ACTIVATEDNR1I3GAMMA-AMINOBUTYRICTHROMBOXANE-AALDO-KETOIDO2TRPM3PEROXISOMEFOXM1

64 known targets mapped from PubChem bioassay data

Pathway Context

Nuclear Receptor transcription pathway12 targets overlapping
Class A/1 (Rhodopsin-like receptors)10 targets overlapping
SUMOylation10 targets overlapping

Uncovered Pathway Targets

202 total
ESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1NR1D2NR1H2+192 more…

Genes present in the top pathway union that Troglitazone does not directly modulate.

Top Stack Candidates

Astemizole Antihistamine drug now withdrawn from

#1 gap-filler · 26 targets covered · evidence score 48.7

score 5,713.46
PPARDADRA2AADRA2CADRB2APLNRAVPR1ACHRM2CHRM3DRD2DRD4GALR2GHSR+14
Aripiprazole

#2 gap-filler · 25 targets covered · evidence score 52.0

score 5,425.599
ADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1AVPR1ACHRM2DRD2+13

706 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.