BiohacksAI/Mechanism Hypothesis/Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.

Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione. — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6ARCYP2C9NR1I2ESR1CYP1A2THRBESRRACYP3A4GLI3PGRRORCNUCLEARTP53NR3C1ABCB1RARAESR2CYP19A1PPARGATAD5CFTRNR1H4SMAD3ALDEHYDESTK33SMAD2NNMTPNMTGAMTGNMTHNMTCATECHOLHSPB1HSP90AA1RGS4HPGDGSK3BHSP90AB1KCNJ2GSK3AFOCALPTK2BTRANSLOCATOR

45 known targets mapped from PubChem bioassay data

Pathway Context

Nuclear Receptor transcription pathway10 targets overlapping

Biological oxidations9 targets overlapping

SUMOylation9 targets overlapping

Uncovered Pathway Targets

114 total

ESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1NR1D2NR1H2+104 more…

Genes present in the top pathway union that Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione. does not directly modulate.

Top Stack Candidates

Progesterone

#1 gap-filler · 13 targets covered · evidence score 50.6

score 3,754.962

ESRRGHNF4AHNF4GNR1H2NR2F1NR3C2NR4A2NR5A1NR5A2RARBRARGRORA+1

Luteolin 5,7,3',4'-tetrahydroxy-flavone,

#2 gap-filler · 14 targets covered · evidence score 40.6

score 3,034.53

NR1H2NR1H3CBR3CYP1A1CYP1B1GSTO1MAOAAURKBBLMNFKB2PARP1RELA+2

513 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.