Activation of BIM and translocation to mitochondria
REACTOME PATHWAYThe Activation of BIM and translocation to mitochondria pathway (Reactome ID: R-HSA-111446) involves 2 genes and is affected by 6 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Activation of BIM and translocation to mitochondria
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Anisomycin | — | 247 |
| 2 | sp600125 | — | 117 |
| 3 | pictilisib | — | 25 |
| 4 | Axitinib | — | 298 |
| 5 | cardamonin | — | 180 |
| 6 | Hesperidin | — | 300 |
About the Activation of BIM and translocation to mitochondria Pathway
The Activation of BIM and translocation to mitochondria pathway is catalogued in Reactome (ID: R-HSA-111446) and involves 2 genes. In the BiohacksAI corpus, 6 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BCL2L11, MAPK8.