Reactome Pathways
Browse 500 Reactome biological pathways with compound interaction data. Each pathway page lists all compounds in the BiohacksAI corpus that target ≥2 genes within the pathway.
Most-Targeted Pathways
Signal Transduction
1070 compoundsR-HSA-162582
Metabolism999 compoundsR-HSA-1430728
Metabolism of proteins845 compoundsR-HSA-392499
Disease838 compoundsR-HSA-1643685
Metabolism of lipids817 compoundsR-HSA-556833
Gene expression (Transcription)817 compoundsR-HSA-74160
RNA Polymerase II Transcription808 compoundsR-HSA-73857
Generic Transcription Pathway802 compoundsR-HSA-212436
Post-translational protein modification778 compoundsR-HSA-597592
Signaling by GPCR749 compoundsR-HSA-372790
Cellular responses to stimuli740 compoundsR-HSA-8953897
Immune System735 compoundsR-HSA-168256
Developmental Biology725 compoundsR-HSA-1266738
GPCR downstream signalling725 compoundsR-HSA-388396
Biological oxidations707 compoundsR-HSA-211859
Cellular responses to stress704 compoundsR-HSA-2262752
Drug ADME693 compoundsR-HSA-9748784
Phase I - Functionalization of compounds690 compoundsR-HSA-211945
GPCR ligand binding670 compoundsR-HSA-500792
Cytochrome P450 - arranged by substrate type669 compoundsR-HSA-211897
All Pathways
Signal Transduction
1070R-HSA-162582
Metabolism999R-HSA-1430728
Metabolism of proteins845R-HSA-392499
Disease838R-HSA-1643685
Metabolism of lipids817R-HSA-556833
Gene expression (Transcription)817R-HSA-74160
RNA Polymerase II Transcription808R-HSA-73857
Generic Transcription Pathway802R-HSA-212436
Post-translational protein modification778R-HSA-597592
Signaling by GPCR749R-HSA-372790
Cellular responses to stimuli740R-HSA-8953897
Immune System735R-HSA-168256
Developmental Biology725R-HSA-1266738
GPCR downstream signalling725R-HSA-388396
Biological oxidations707R-HSA-211859
Cellular responses to stress704R-HSA-2262752
Drug ADME693R-HSA-9748784
Phase I - Functionalization of compounds690R-HSA-211945
GPCR ligand binding670R-HSA-500792
Cytochrome P450 - arranged by substrate type669R-HSA-211897
Class A/1 (Rhodopsin-like receptors)652R-HSA-373076
SUMOylation644R-HSA-2990846
SUMO E3 ligases SUMOylate target proteins643R-HSA-3108232
Infectious disease623R-HSA-5663205
Xenobiotics621R-HSA-211981
Cytokine Signaling in Immune system600R-HSA-1280215
Fatty acid metabolism597R-HSA-8978868
Biosynthesis of DHA-derived SPMs596R-HSA-9018677
Biosynthesis of specialized proresolving mediators (SPMs)596R-HSA-9018678
Nuclear Receptor transcription pathway595R-HSA-383280
Viral Infection Pathways577R-HSA-9824446
Signaling by Interleukins576R-HSA-449147
Aspirin ADME575R-HSA-9749641
Arachidonate metabolism569R-HSA-2142753
SUMOylation of intracellular receptors567R-HSA-4090294
Deubiquitination556R-HSA-5688426
Biosynthesis of maresins554R-HSA-9018682
Biosynthesis of maresin-like SPMs545R-HSA-9027307
Transport of small molecules541R-HSA-382551
Signaling by Nuclear Receptors536R-HSA-9006931
SARS-CoV Infections530R-HSA-9679506
Hemostasis529R-HSA-109582
Transcriptional regulation by RUNX2527R-HSA-8878166
Signaling by Receptor Tyrosine Kinases518R-HSA-9006934
Innate Immune System510R-HSA-168249
Diseases of signal transduction by growth factor receptors and second messengers503R-HSA-5663202
CYP2E1 reactions501R-HSA-211999
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)492R-HSA-2142670
Neuronal System490R-HSA-112316
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)489R-HSA-2142816
Intracellular signaling by second messengers488R-HSA-9006925
G alpha (q) signalling events488R-HSA-416476
Adaptive Immune System483R-HSA-1280218
Ub-specific processing proteases480R-HSA-5689880
ESR-mediated signaling480R-HSA-8939211
PIP3 activates AKT signaling476R-HSA-1257604
G alpha (i) signalling events474R-HSA-418594
Potential therapeutics for SARS462R-HSA-9679191
Developmental Cell Lineages450R-HSA-9734767
Signaling by Rho GTPases, Miro GTPases and RHOBTB3441R-HSA-9716542
Amine ligand-binding receptors434R-HSA-375280
Estrogen-dependent gene expression430R-HSA-9018519
Cellular response to chemical stress420R-HSA-9711123
Signaling by Rho GTPases414R-HSA-194315
RUNX2 regulates bone development413R-HSA-8941326
RUNX2 regulates osteoblast differentiation411R-HSA-8940973
Platelet activation, signaling and aggregation408R-HSA-76002
G alpha (s) signalling events399R-HSA-418555
Regulation of RUNX2 expression and activity396R-HSA-8939902
Transmission across Chemical Synapses388R-HSA-112315
Signaling by ERBB4386R-HSA-1236394
Cell Cycle383R-HSA-1640170
Leishmania infection382R-HSA-9658195
Parasitic Infection Pathways382R-HSA-9824443
Developmental Cell Lineages of the Integumentary System381R-HSA-9734779
PPARA activates gene expression381R-HSA-1989781
Regulation of lipid metabolism by PPARalpha381R-HSA-400206
RHO GTPase Effectors377R-HSA-195258
Extra-nuclear estrogen signaling376R-HSA-9009391
Transcriptional regulation by RUNX1373R-HSA-8878171
Nuclear signaling by ERBB4368R-HSA-1251985
Interleukin-4 and Interleukin-13 signaling364R-HSA-6785807
Aflatoxin activation and detoxification363R-HSA-5423646
PI3K/AKT Signaling in Cancer362R-HSA-2219528
Organelle biogenesis and maintenance362R-HSA-1852241
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand360R-HSA-3371497
Regulation of T cell activation by CD28 family358R-HSA-388841
DNA Repair348R-HSA-73894
Atorvastatin ADME347R-HSA-9754706
Ovarian tumor domain proteases346R-HSA-5689896
Co-inhibition by PD-1344R-HSA-389948
Developmental Lineages of the Mammary Gland342R-HSA-9924644
Prednisone ADME342R-HSA-9757110
Developmental Lineage of Mammary Gland Luminal Epithelial Cells340R-HSA-9927418
Regulation of PD-L1(CD274) expression339R-HSA-9909648
Developmental Lineage of Mammary Gland Alveolar Cells337R-HSA-9927426
DNA Double-Strand Break Repair335R-HSA-5693532
Negative regulation of the PI3K/AKT network333R-HSA-199418
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling332R-HSA-6811558
Metabolism of steroids329R-HSA-8957322
Vesicle-mediated transport329R-HSA-5653656
KEAP1-NFE2L2 pathway328R-HSA-9755511
Fatty acids326R-HSA-211935
Cell Cycle Checkpoints326R-HSA-69620
Miscellaneous substrates325R-HSA-211958
Platelet Aggregation (Plug Formation)324R-HSA-76009
Transcriptional Regulation by TP53323R-HSA-3700989
Mitochondrial biogenesis317R-HSA-1592230
Regulation of PD-L1(CD274) transcription316R-HSA-9909649
Constitutive Signaling by Aberrant PI3K in Cancer315R-HSA-2219530
Signaling by NOTCH315R-HSA-157118
Nuclear events mediated by NFE2L2311R-HSA-9759194
RHO GTPases activate PKNs306R-HSA-5625740
G2/M Checkpoints305R-HSA-69481
Transcriptional activation of mitochondrial biogenesis304R-HSA-2151201
Membrane Trafficking302R-HSA-199991
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3301R-HSA-5625886
Cytoprotection by HMOX1301R-HSA-9707564
G2/M DNA damage checkpoint301R-HSA-69473
Fc epsilon receptor (FCERI) signaling299R-HSA-2454202
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks295R-HSA-5693565
DNA Double Strand Break Response295R-HSA-5693606
Interferon Signaling293R-HSA-913531
Toll-like Receptor Cascades289R-HSA-168898
Cell Cycle, Mitotic289R-HSA-69278
Heme signaling287R-HSA-9707616
Toll Like Receptor 3 (TLR3) Cascade285R-HSA-168164
PTEN Regulation284R-HSA-6807070
Toll Like Receptor 9 (TLR9) Cascade282R-HSA-168138
Cellular Senescence282R-HSA-2559583
Toll Like Receptor 4 (TLR4) Cascade281R-HSA-166016
MyD88:MAL(TIRAP) cascade initiated on plasma membrane280R-HSA-166058
MyD88-independent TLR4 cascade280R-HSA-166166
Toll Like Receptor TLR1:TLR2 Cascade280R-HSA-168179
Toll Like Receptor 7/8 (TLR7/8) Cascade280R-HSA-168181
Toll Like Receptor TLR6:TLR2 Cascade280R-HSA-168188
Toll Like Receptor 2 (TLR2) Cascade280R-HSA-181438
TRIF (TICAM1)-mediated TLR4 signaling280R-HSA-937061
Nervous system development280R-HSA-9675108
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors279R-HSA-8864260
Toll Like Receptor 10 (TLR10) Cascade279R-HSA-168142
Toll Like Receptor 5 (TLR5) Cascade279R-HSA-168176
Interleukin-1 family signaling279R-HSA-446652
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation279R-HSA-975138
MyD88 dependent cascade initiated on endosome279R-HSA-975155
MyD88 cascade initiated on plasma membrane279R-HSA-975871
C-type lectin receptors (CLRs)278R-HSA-5621481
Disorders of transmembrane transporters275R-HSA-5619115
CLEC7A (Dectin-1) signaling273R-HSA-5607764
Regulation of PTEN gene transcription273R-HSA-8943724
Chromatin modifying enzymes271R-HSA-3247509
Chromatin organization271R-HSA-4839726
Anti-inflammatory response favouring Leishmania parasite infection269R-HSA-9662851
Leishmania parasite growth and survival269R-HSA-9664433
Phase II - Conjugation of compounds268R-HSA-156580
Signaling by ALK in cancer268R-HSA-9700206
Signaling by ALK fusions and activated point mutants268R-HSA-9725370
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors264R-HSA-8866910
Mitochondrial unfolded protein response (UPRmt)264R-HSA-9841251
FCERI mediated MAPK activation264R-HSA-2871796
Methylation262R-HSA-156581
Transcriptional Regulation by MECP2262R-HSA-8986944
Neddylation261R-HSA-8951664
Homology Directed Repair261R-HSA-5693538
Neutrophil degranulation259R-HSA-6798695
Endogenous sterols258R-HSA-211976
RUNX1 regulates estrogen receptor mediated transcription257R-HSA-8931987
RUNX1 regulates transcription of genes involved in WNT signaling257R-HSA-8939256
SLC-mediated transmembrane transport257R-HSA-425407
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)256R-HSA-5693567
Signaling by TGFB family members255R-HSA-9006936
Transcriptional regulation by RUNX3254R-HSA-8878159
Regulation of TP53 Activity251R-HSA-5633007
Oxidative Stress Induced Senescence250R-HSA-2559580
Metabolism of amino acids and derivatives249R-HSA-71291
Axon guidance249R-HSA-422475
Biosynthesis of protectins248R-HSA-9018681
Muscle contraction248R-HSA-397014
Integration of energy metabolism247R-HSA-163685
Signaling by Hedgehog246R-HSA-5358351
Signaling by the B Cell Receptor (BCR)245R-HSA-983705
Interleukin-1 signaling245R-HSA-9020702
Diseases of programmed cell death243R-HSA-9645723
Fcgamma receptor (FCGR) dependent phagocytosis242R-HSA-2029480
FCGR3A-mediated IL10 synthesis242R-HSA-9664323
Integrin signaling241R-HSA-354192
Programmed Cell Death239R-HSA-5357801
Peptide ligand-binding receptors239R-HSA-375276
NFE2L2 regulating MDR associated enzymes238R-HSA-9818032
Clathrin-mediated endocytosis237R-HSA-8856828
Cardiac conduction236R-HSA-5576891
Activation of anterior HOX genes in hindbrain development during early embryogenesis235R-HSA-5617472
Activation of HOX genes during differentiation235R-HSA-5619507
Regulation of actin dynamics for phagocytic cup formation234R-HSA-2029482
ABC-family proteins mediated transport234R-HSA-382556
Hedgehog 'off' state233R-HSA-5610787
Cargo recognition for clathrin-mediated endocytosis233R-HSA-8856825
Defective Intrinsic Pathway for Apoptosis232R-HSA-9734009
Transcriptional Regulation by NPAS4232R-HSA-9634815
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2230R-HSA-211957
Epigenetic regulation of gene expression230R-HSA-212165
MAPK family signaling cascades230R-HSA-5683057
NFE2L2 regulating TCA cycle genes229R-HSA-9818025
Regulation of NFE2L2 gene expression227R-HSA-9818749
Parasite infection227R-HSA-9664407
Leishmania phagocytosis227R-HSA-9664417
FCGR3A-mediated phagocytosis227R-HSA-9664422
Neurotransmitter receptors and postsynaptic signal transmission226R-HSA-112314
Processing of DNA double-strand break ends223R-HSA-5693607
Regulation of TP53 Activity through Phosphorylation223R-HSA-6804756
Pre-NOTCH Expression and Processing222R-HSA-1912422
Regulation of insulin secretion221R-HSA-422356
Pre-NOTCH Transcription and Translation219R-HSA-1912408
TP53 Regulates Transcription of DNA Repair Genes219R-HSA-6796648
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2218R-HSA-9762114
Interleukin-2 family signaling218R-HSA-451927
Transcriptional regulation of granulopoiesis218R-HSA-9616222
DAP12 interactions217R-HSA-2172127
GLI3 is processed to GLI3R by the proteasome216R-HSA-5610785
PKMTs methylate histone lysines216R-HSA-3214841
Antimicrobial mechanism of IFN-stimulated genes216R-HSA-1169410
Interleukin-3, Interleukin-5 and GM-CSF signaling215R-HSA-512988
FLT3 Signaling215R-HSA-9607240
GPVI-mediated activation cascade214R-HSA-114604
Hedgehog 'on' state214R-HSA-5632684
Potassium Channels214R-HSA-1296071
NFE2L2 regulating tumorigenic genes213R-HSA-9818030
FOXO-mediated transcription213R-HSA-9614085
DAP12 signaling210R-HSA-2424491
Regulation of signaling by CBL210R-HSA-912631
Signaling by CSF3 (G-CSF)210R-HSA-9674555
TAK1-dependent IKK and NF-kappa-B activation210R-HSA-445989
Regulated Necrosis210R-HSA-5218859
Factors involved in megakaryocyte development and platelet production210R-HSA-983231
Signaling by PTK6210R-HSA-8848021
Signaling by Non-Receptor Tyrosine Kinases210R-HSA-9006927
NFE2L2 regulates pentose phosphate pathway genes209R-HSA-9818028
Role of LAT2/NTAL/LAB on calcium mobilization209R-HSA-2730905
Inactivation of CSF3 (G-CSF) signaling209R-HSA-9705462
FLT3 signaling through SRC family kinases209R-HSA-9706374
Mitotic G2-G2/M phases209R-HSA-453274
G2/M Transition209R-HSA-69275
NFE2L2 regulating anti-oxidant/detoxification enzymes208R-HSA-9818027
FCGR activation208R-HSA-2029481
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers208R-HSA-983695
Nonhomologous End-Joining (NHEJ)208R-HSA-5693571
NFE2L2 regulating inflammation associated genes207R-HSA-9818026
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes207R-HSA-9615017
NFE2L2 regulating ER-stress associated genes206R-HSA-9818035
Dectin-2 family206R-HSA-5621480
Maternal to zygotic transition (MZT)206R-HSA-9816359
Adrenoceptors206R-HSA-390696
Role of phospholipids in phagocytosis205R-HSA-2029485
Interleukin-2 signaling205R-HSA-9020558
FCERI mediated Ca+2 mobilization203R-HSA-2871809
Signaling by TGFBR3203R-HSA-9839373
Regulation of HMOX1 expression and activity202R-HSA-9707587
Dopamine receptors202R-HSA-390651
TP53 Regulates Metabolic Genes201R-HSA-5628897
Epigenetic regulation by WDR5-containing histone modifying complexes201R-HSA-9917777
G1/S DNA Damage Checkpoints199R-HSA-69615
Diseases of metabolism199R-HSA-5668914
Bile acid and bile salt metabolism199R-HSA-194068
Opioid Signalling199R-HSA-111885
Cellular responses to mechanical stimuli199R-HSA-9855142
PKR-mediated signaling196R-HSA-9833482
TGFBR3 expression195R-HSA-9839394
GLI proteins bind promoters of Hh responsive genes to promote transcription194R-HSA-5635851
Regulation of TP53 Degradation194R-HSA-6804757
Regulation of TP53 Expression and Degradation194R-HSA-6806003
Regulation of TP53 Activity through Methylation193R-HSA-6804760
Serotonin receptors193R-HSA-390666
Neurotransmitter clearance193R-HSA-112311
Transcriptional regulation of white adipocyte differentiation191R-HSA-381340
Adipogenesis191R-HSA-9843745
Autophagy191R-HSA-9612973
Apoptosis190R-HSA-109581
SUMOylation of transcription factors190R-HSA-3232118
Pyroptosis190R-HSA-5620971
Transcriptional Regulation by VENTX190R-HSA-8853884
Signaling by Retinoic Acid190R-HSA-5362517
Recycling of bile acids and salts190R-HSA-159418
Macroautophagy187R-HSA-1632852
Metabolism of vitamins and cofactors187R-HSA-196854
The role of GTSE1 in G2/M progression after G2 checkpoint186R-HSA-8852276
Response of endothelial cells to shear stress186R-HSA-9860931
Oncogene Induced Senescence184R-HSA-2559585
PTK6 Expression184R-HSA-8849473
p53-Dependent G1 DNA Damage Response182R-HSA-69563
p53-Dependent G1/S DNA damage checkpoint182R-HSA-69580
Interleukin-17 signaling181R-HSA-448424
MAP kinase activation181R-HSA-450294
Intrinsic Pathway for Apoptosis180R-HSA-109606
Stabilization of p53180R-HSA-69541
TP53 Regulates Transcription of Cell Cycle Genes179R-HSA-6791312
Chaperonin-mediated protein folding178R-HSA-390466
Protein folding178R-HSA-391251
RUNX3 regulates CDKN1A transcription178R-HSA-8941855
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes178R-HSA-9818564
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis178R-HSA-9841922
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes178R-HSA-9851695
Circadian clock178R-HSA-9909396
Zygotic genome activation (ZGA)177R-HSA-9819196
Abacavir transmembrane transport176R-HSA-2161517
Abacavir ADME176R-HSA-2161522
MITF-M-regulated melanocyte development176R-HSA-9730414
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest175R-HSA-6804114
Regulation of TP53 Activity through Acetylation173R-HSA-6804758
Developmental Cell Lineages of the Exocrine Pancreas173R-HSA-9820448
Selective autophagy170R-HSA-9663891
Interleukin-12 family signaling167R-HSA-447115
PI5P Regulates TP53 Acetylation166R-HSA-6811555
G alpha (z) signalling events165R-HSA-418597
RHO GTPase cycle164R-HSA-9012999
SARS-CoV-2 Infection164R-HSA-9694516
Interleukin-12 signaling163R-HSA-9020591
Synthesis of bile acids and bile salts163R-HSA-192105
Association of TriC/CCT with target proteins during biosynthesis162R-HSA-390471
TP53 Regulates Transcription of Cell Death Genes162R-HSA-5633008
SLC transporter disorders161R-HSA-5619102
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol161R-HSA-193368
TP53 Regulates Transcription of Caspase Activators and Caspases159R-HSA-6803207
Urea cycle159R-HSA-70635
Voltage gated Potassium channels159R-HSA-1296072
Muscarinic acetylcholine receptors159R-HSA-390648
Activation of BH3-only proteins158R-HSA-114452
Autodegradation of the E3 ubiquitin ligase COP1157R-HSA-349425
DNA Damage/Telomere Stress Induced Senescence156R-HSA-2559586
Regulation of NF-kappa B signaling156R-HSA-9758274
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest155R-HSA-6804116
Phase 3 - rapid repolarisation155R-HSA-5576890
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation155R-HSA-8950505
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release154R-HSA-6803204
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain154R-HSA-6804115
Cell-Cell communication154R-HSA-1500931
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain152R-HSA-6803205
Regulation of TP53 Activity through Association with Co-factors152R-HSA-6804759
Activation of NOXA and translocation to mitochondria151R-HSA-111448
Activation of PUMA and translocation to mitochondria151R-HSA-139915
Formation of Senescence-Associated Heterochromatin Foci (SAHF)151R-HSA-2559584
TP53 Regulates Transcription of Death Receptors and Ligands151R-HSA-6803211
Regulation of TP53 Expression151R-HSA-6804754
Transcriptional activation of p53 responsive genes151R-HSA-69560
Transcriptional activation of cell cycle inhibitor p21151R-HSA-69895
Loss of function of TP53 in cancer due to loss of tetramerization ability151R-HSA-9723905
Loss of Function of TP53 in Cancer151R-HSA-9723907
Regulation of NPAS4 gene expression151R-HSA-9768759
Regulation of NPAS4 gene transcription150R-HSA-9768777
Interferon gamma signaling150R-HSA-877300
SARS-CoV-1 Infection150R-HSA-9678108
Metabolic disorders of biological oxidation enzymes149R-HSA-5579029
Mitotic G1 phase and G1/S transition149R-HSA-453279
ABC transporter disorders146R-HSA-5619084
Senescence-Associated Secretory Phenotype (SASP)145R-HSA-2559582
Adherens junctions interactions145R-HSA-418990
Cell-cell junction organization145R-HSA-421270
Cell junction organization145R-HSA-446728
Regulation of Homotypic Cell-Cell Adhesion145R-HSA-9759476
Regulation of CDH1 Expression and Function145R-HSA-9764265
Regulation of Expression and Function of Type I Classical Cadherins145R-HSA-9764274
Transcriptional and post-translational regulation of MITF-M expression and activity145R-HSA-9856649
G alpha (12/13) signalling events144R-HSA-416482
MAPK targets/ Nuclear events mediated by MAP kinases144R-HSA-450282
Transcriptional regulation of brown and beige adipocyte differentiation143R-HSA-9843743
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2143R-HSA-9844594
MAPK6/MAPK4 signaling142R-HSA-5687128
MECP2 regulates neuronal receptors and channels142R-HSA-9022699
Gastrulation140R-HSA-9758941
MITF-M-dependent gene expression140R-HSA-9856651
Sensory Perception140R-HSA-9709957
Developmental Lineage of Pancreatic Ductal Cells139R-HSA-9925563
Expression of BMAL (ARNTL), CLOCK, and NPAS2139R-HSA-9931509
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells137R-HSA-9860927
Aggrephagy136R-HSA-9646399
Signaling by TGF-beta Receptor Complex134R-HSA-170834
MAPK1/MAPK3 signaling134R-HSA-5684996
SARS-CoV-1-host interactions132R-HSA-9692914
Purinergic signaling in leishmaniasis infection132R-HSA-9660826
Cell recruitment (pro-inflammatory response)132R-HSA-9664424
SARS-CoV-2-host interactions131R-HSA-9705683
Signaling by NOTCH1131R-HSA-1980143
Metabolism of steroid hormones130R-HSA-196071
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways130R-HSA-168643
Adrenaline,noradrenaline inhibits insulin secretion128R-HSA-400042
Synthesis of bile acids and bile salts via 27-hydroxycholesterol128R-HSA-193807
SLC-mediated transport of neurotransmitters127R-HSA-442660
Constitutive Signaling by AKT1 E17K in Cancer127R-HSA-5674400
DDX58/IFIH1-mediated induction of interferon-alpha/beta127R-HSA-168928
RAF/MAP kinase cascade127R-HSA-5673001
Signaling by VEGF125R-HSA-194138
Metabolism of RNA125R-HSA-8953854
Peptide hormone metabolism124R-HSA-2980736
VEGFA-VEGFR2 Pathway124R-HSA-4420097
NOTCH1 Intracellular Domain Regulates Transcription123R-HSA-2122947
Chaperone Mediated Autophagy122R-HSA-9613829
Interleukin-10 signaling122R-HSA-6783783
S Phase121R-HSA-69242
Respiratory Syncytial Virus Infection Pathway121R-HSA-9820952
Signaling by NTRKs121R-HSA-166520
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models120R-HSA-8862803
Neurodegenerative Diseases120R-HSA-8863678
G1/S Transition120R-HSA-69206
SARS-CoV-2 activates/modulates innate and adaptive immune responses120R-HSA-9705671
Protein localization119R-HSA-9609507
Post NMDA receptor activation events118R-HSA-438064
Activation of NMDA receptors and postsynaptic events118R-HSA-442755
Cellular response to heat stress118R-HSA-3371556
Dengue Virus Infection117R-HSA-9839923
M Phase116R-HSA-68886
HCMV Infection114R-HSA-9609646
HCMV Early Events114R-HSA-9609690
Phospholipid metabolism113R-HSA-1483257
Adrenaline signalling through Alpha-2 adrenergic receptor112R-HSA-392023
MECP2 regulates transcription factors112R-HSA-9022707
G-protein mediated events112R-HSA-112040
Aryl hydrocarbon receptor signalling111R-HSA-8937144
Regulation of IFNG signaling110R-HSA-877312
Synthesis of 15-eicosatetraenoic acid derivatives110R-HSA-2142770
Platelet homeostasis110R-HSA-418346
IFNG signaling activates MAPKs109R-HSA-9732724
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer109R-HSA-2173793
Biosynthesis of EPA-derived SPMs109R-HSA-9018679
NCAM signaling for neurite out-growth109R-HSA-375165
Surfactant metabolism108R-HSA-5683826
Signaling by NOTCH4108R-HSA-9013694
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression107R-HSA-9933387
Activation of the AP-1 family of transcription factors106R-HSA-450341
Regulation of cholesterol biosynthesis by SREBP (SREBF)105R-HSA-1655829
Estrogen biosynthesis103R-HSA-193144
Activation of gene expression by SREBF (SREBP)103R-HSA-2426168
NR1H2 and NR1H3-mediated signaling103R-HSA-9024446
Defective CYP19A1 causes AEXS102R-HSA-5579030
Downregulation of SMAD2/3:SMAD4 transcriptional activity102R-HSA-2173795
PLC beta mediated events102R-HSA-112043
Metabolism of water-soluble vitamins and cofactors102R-HSA-196849
Inflammasomes102R-HSA-622312
DNA Replication101R-HSA-69306
L1CAM interactions101R-HSA-373760
Serotonin clearance from the synaptic cleft100R-HSA-380615
Late endosomal microautophagy100R-HSA-9615710
NPAS4 regulates expression of target genes100R-HSA-9768919
Signaling by NTRK1 (TRKA)100R-HSA-187037
Regulation of MECP2 expression and activity100R-HSA-9022692
Neurotransmitter release cycle100R-HSA-112310
Metabolism of porphyrins100R-HSA-189445
Cellular response to hypoxia99R-HSA-1234174
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)98R-HSA-9942503
Differentiation of T cells98R-HSA-9945266
Dopamine clearance from the synaptic cleft98R-HSA-379401
Cilium Assembly98R-HSA-5617833
Heme degradation98R-HSA-189483
Synthesis of DNA97R-HSA-69239
Carnitine shuttle96R-HSA-200425
Regulation of MITF-M-dependent genes involved in pigmentation96R-HSA-9824585
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription95R-HSA-2173796
Ca-dependent events95R-HSA-111996
Biosynthesis of DPA-derived SPMs94R-HSA-9018683
Biosynthesis of DPAn-3 SPMs94R-HSA-9025094
Signaling by NOTCH1 PEST Domain Mutants in Cancer94R-HSA-2644602
Signaling by NOTCH1 in Cancer94R-HSA-2644603
Constitutive Signaling by NOTCH1 PEST Domain Mutants94R-HSA-2644606
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer94R-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants94R-HSA-2894862
The NLRP3 inflammasome94R-HSA-844456
Mitotic Prometaphase94R-HSA-68877
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)93R-HSA-8877330
Hormone ligand-binding receptors93R-HSA-375281
Glycerophospholipid biosynthesis93R-HSA-1483206
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux93R-HSA-9029569
Synthesis, secretion, and deacylation of Ghrelin92R-HSA-422085
HDR through Homologous Recombination (HRR)92R-HSA-5685942
Regulation of gene expression by Hypoxia-inducible Factor92R-HSA-1234158
Extracellular matrix organization92R-HSA-1474244
TGF-beta receptor signaling activates SMADs91R-HSA-2173789
Formation of axial mesoderm91R-HSA-9796292
Interleukin-1 processing91R-HSA-448706
NOTCH4 Intracellular Domain Regulates Transcription90R-HSA-9013695
Bacterial Infection Pathways90R-HSA-9824439
BMAL1:CLOCK,NPAS2 activates circadian expression89R-HSA-1368108
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling89R-HSA-442742
Nuclear Events (kinase and transcription factor activation)88R-HSA-198725
Class I MHC mediated antigen processing & presentation88R-HSA-983169
SUMOylation of DNA damage response and repair proteins88R-HSA-3108214
Signaling by NODAL86R-HSA-1181150
Signaling by ALK86R-HSA-201556
HDR through Single Strand Annealing (SSA)86R-HSA-5685938
Dengue Virus-Host Interactions86R-HSA-9918481
SLC-mediated transport of organic anions86R-HSA-9955298
Synthesis of PC85R-HSA-1483191
Interleukin-37 signaling84R-HSA-9008059
Regulation of RUNX3 expression and activity84R-HSA-8941858
CLEC7A/inflammasome pathway84R-HSA-5660668
Synthesis of 12-eicosatetraenoic acid derivatives84R-HSA-2142712
Metabolism of cofactors83R-HSA-8978934
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation83R-HSA-9825892
RUNX1 regulates transcription of genes involved in differentiation of HSCs83R-HSA-8939236
TCR signaling83R-HSA-202403
Killing mechanisms82R-HSA-9664420
WNT5:FZD7-mediated leishmania damping82R-HSA-9673324
Signaling by Activin82R-HSA-1502540