Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
REACTOME PATHWAYThe Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation pathway (Reactome ID: R-HSA-163841) involves 9 genes and is affected by 15 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Rivaroxaban | — | 999 |
| 2 | apixaban [Supplementary Concept] | — | 997 |
| 3 | Gabexate | — | 300 |
| 4 | Deferoxamine Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as | — | 296 |
| 5 | Mimosine 3-Hydroxy-4-oxo-1(4H)-pyridinealanine. | — | 300 |
| 6 | stx64 | — | 2 |
| 7 | Dehydroepiandrosterone Sulfate | — | 300 |
| 8 | Diminazene | — | 300 |
| 9 | silver sulfadiazine | — | 299 |
| 10 | piceatannol | — | 300 |
| 11 | pirenperone | — | 22 |
| 12 | Simvastatin | — | 1,000 |
| 13 | Vitamin K 2 | — | 300 |
| 14 | cycloheximide | — | 300 |
| 15 | Plicamycin | — | 72 |
About the Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation Pathway
The Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation pathway is catalogued in Reactome (ID: R-HSA-163841) and involves 9 genes. In the BiohacksAI corpus, 15 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ARSA, ASPH, DOHH, EEF2, F10.