Nef mediated downregulation of MHC class I complex cell surface expression
REACTOME PATHWAYThe Nef mediated downregulation of MHC class I complex cell surface expression pathway (Reactome ID: R-HSA-164940) involves 1 genes and is affected by 1 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Nef mediated downregulation of MHC class I complex cell surface expression
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Astemizole Antihistamine drug now withdrawn from | — | 280 |
About the Nef mediated downregulation of MHC class I complex cell surface expression Pathway
The Nef mediated downregulation of MHC class I complex cell surface expression pathway is catalogued in Reactome (ID: R-HSA-164940) and involves 1 genes. In the BiohacksAI corpus, 1 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include HLA-A.