NRIF signals cell death from the nucleus
REACTOME PATHWAYThe NRIF signals cell death from the nucleus pathway (Reactome ID: R-HSA-205043) involves 7 genes and is affected by 7 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting NRIF signals cell death from the nucleus
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Dihydroergocristine | — | 187 |
| 2 | sp600125 | — | 117 |
| 3 | Anisomycin | — | 247 |
| 4 | pictilisib | — | 25 |
| 5 | Axitinib | — | 298 |
| 6 | cardamonin | — | 180 |
| 7 | Hesperidin | — | 300 |
About the NRIF signals cell death from the nucleus Pathway
The NRIF signals cell death from the nucleus pathway is catalogued in Reactome (ID: R-HSA-205043) and involves 7 genes. In the BiohacksAI corpus, 7 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include APH1A, APH1B, MAPK8, NCSTN, PSEN1.