What compounds affect the Integrin cell surface interactions pathway?

33 compounds in the BiohacksAI corpus have documented interactions with genes in the Integrin cell surface interactions pathway (Reactome ID: R-HSA-216083). These compounds target 8 genes within this pathway.

What genes are in the Integrin cell surface interactions pathway?

The Integrin cell surface interactions pathway involves 8 genes. Key genes include: CD47, ICAM1, ITGA2B, ITGA4, ITGAV, ITGB2, ITGB3, KDR.

Integrin cell surface interactions

REACTOME PATHWAY

Reactome: R-HSA-2160838 genes33 compounds

The Integrin cell surface interactions pathway (Reactome ID: R-HSA-216083) involves 8 genes and is affected by 33 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CD47 ICAM1 ITGA2B ITGA4 ITGAV ITGB2 ITGB3 KDR

Compounds Affecting Integrin cell surface interactions

#	Compound	Targets Hit	Studies
1	Tirofiban Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in	—	299
2	Lovastatin	—	300
3	Inositol	—	300
4	Phenylbutazone	—	300
5	Sulfinpyrazone	—	300
6	Chlorogenic Acid	—	300
7	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
8	Prednisolone	—	1,000
9	Astemizole Antihistamine drug now withdrawn from	—	280
10	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
11	Enoximone	—	300
12	Isocarboxazid	—	227
13	Oxaprozin	—	181
14	Quinestrol	—	194
15	Ranolazine	—	297
16	Semustine 4-Methyl derivative of LOMUSTINE; (CCNU).	—	97
17	sulfameter	—	52
18	sulfamonomethoxine	—	253
19	Sorafenib	—	300
20	Axitinib	—	298
21	Quercetin	—	300
22	Avapritinib	—	246
23	Crizotinib	—	298
24	Dasatinib	—	299
25	kenpaullone	—	8
26	sp600125	—	117
27	tyrphostin ag 1295	—	1
28	Vemurafenib	—	298
29	Aurintricarboxylic Acid	—	184
30	Histidine	—	158
31	Fusaric Acid	—	300
32	Idarubicin	—	299
33	Mimosine 3-Hydroxy-4-oxo-1(4H)-pyridinealanine.	—	300

About the Integrin cell surface interactions Pathway

The Integrin cell surface interactions pathway is catalogued in Reactome (ID: R-HSA-216083) and involves 8 genes. In the BiohacksAI corpus, 33 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CD47, ICAM1, ITGA2B, ITGA4, ITGAV.