Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
REACTOME PATHWAYThe Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling pathway (Reactome ID: R-HSA-2644607) involves 2 genes and is affected by 3 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | ninhydrin | — | 300 |
| 2 | candesartan cilexetil [Supplementary Concept] | — | 300 |
| 3 | Cetylpyridinium Cationic bactericidal surfactant used as | — | 300 |
About the Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling Pathway
The Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling pathway is catalogued in Reactome (ID: R-HSA-2644607) and involves 2 genes. In the BiohacksAI corpus, 3 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CUL1, RBX1.