Loss of Function of TGFBR2 in Cancer
REACTOME PATHWAYThe Loss of Function of TGFBR2 in Cancer pathway (Reactome ID: R-HSA-3642278) involves 2 genes and is affected by 5 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Loss of Function of TGFBR2 in Cancer
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Dasatinib | — | 299 |
| 2 | Hesperidin | — | 300 |
| 3 | Sorafenib | — | 300 |
| 4 | Vemurafenib | — | 298 |
| 5 | Crizotinib | — | 298 |
About the Loss of Function of TGFBR2 in Cancer Pathway
The Loss of Function of TGFBR2 in Cancer pathway is catalogued in Reactome (ID: R-HSA-3642278) and involves 2 genes. In the BiohacksAI corpus, 5 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include TGFBR1, TGFBR2.