Disassembly of the destruction complex and recruitment of AXIN to the membrane
REACTOME PATHWAYThe Disassembly of the destruction complex and recruitment of AXIN to the membrane pathway (Reactome ID: R-HSA-4641262) involves 6 genes and is affected by 21 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Disassembly of the destruction complex and recruitment of AXIN to the membrane
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | sp600125 | — | 117 |
| 2 | alsterpaullone | — | 12 |
| 3 | Sorafenib | — | 300 |
| 4 | Okadaic Acid | — | 300 |
| 5 | kenpaullone | — | 8 |
| 6 | indirubin | — | 300 |
| 7 | Apigenin 5,7,4'-trihydroxy-flavone, | — | 300 |
| 8 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 9 | Kaempferols | — | 300 |
| 10 | Quercetin | — | 300 |
| 11 | Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is | — | 300 |
| 12 | Lithium Chloride | — | 300 |
| 13 | chrysin | — | 300 |
| 14 | fisetin | — | 78 |
| 15 | ly294002 | — | 11 |
| 16 | egcg | — | 300 |
| 17 | Rutin | — | 300 |
| 18 | Ursolic Acid | — | 300 |
| 19 | Oleanolic Acid | — | 300 |
| 20 | Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione. | — | 300 |
| 21 | Niclosamide | — | 299 |
About the Disassembly of the destruction complex and recruitment of AXIN to the membrane Pathway
The Disassembly of the destruction complex and recruitment of AXIN to the membrane pathway is catalogued in Reactome (ID: R-HSA-4641262) and involves 6 genes. In the BiohacksAI corpus, 21 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CSNK1A1, CSNK1G2, FZD1, GSK3B, PPP2CA.