What compounds affect the Signaling by WNT in cancer pathway?

26 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by WNT in cancer pathway (Reactome ID: R-HSA-4791275). These compounds target 8 genes within this pathway.

What genes are in the Signaling by WNT in cancer pathway?

The Signaling by WNT in cancer pathway involves 8 genes. Key genes include: CSNK1A1, CTBP1, GSK3B, PPP2CA, PPP2R5A, TCF7L2, TNKS, TNKS2.

Signaling by WNT in cancer

REACTOME PATHWAY

Reactome: R-HSA-47912758 genes26 compounds

The Signaling by WNT in cancer pathway (Reactome ID: R-HSA-4791275) involves 8 genes and is affected by 26 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CSNK1A1 CTBP1 GSK3B PPP2CA PPP2R5A TCF7L2 TNKS TNKS2

Compounds Affecting Signaling by WNT in cancer

#	Compound	Targets Hit	Studies
1	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
2	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
3	Sorafenib	—	300
4	sp600125	—	117
5	Okadaic Acid	—	300
6	alsterpaullone	—	12
7	kenpaullone	—	8
8	indirubin	—	300
9	Kaempferols	—	300
10	Quercetin	—	300
11	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
12	Lithium Chloride	—	300
13	chrysin	—	300
14	fisetin	—	78
15	ly294002	—	11
16	egcg	—	300
17	Rutin	—	300
18	Ursolic Acid	—	300
19	Oleanolic Acid	—	300
20	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
21	NAD	—	300
22	NAD	—	300
23	NAD	—	300
24	Carmine Coloring matter from	—	300
25	Diiodotyrosine	—	300
26	pnu74654	—	6

About the Signaling by WNT in cancer Pathway

The Signaling by WNT in cancer pathway is catalogued in Reactome (ID: R-HSA-4791275) and involves 8 genes. In the BiohacksAI corpus, 26 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CSNK1A1, CTBP1, GSK3B, PPP2CA, PPP2R5A.