APC truncation mutants have impaired AXIN binding
REACTOME PATHWAYThe APC truncation mutants have impaired AXIN binding pathway (Reactome ID: R-HSA-5467337) involves 4 genes and is affected by 20 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting APC truncation mutants have impaired AXIN binding
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Sorafenib | — | 300 |
| 2 | sp600125 | — | 117 |
| 3 | Okadaic Acid | — | 300 |
| 4 | alsterpaullone | — | 12 |
| 5 | kenpaullone | — | 8 |
| 6 | indirubin | — | 300 |
| 7 | Apigenin 5,7,4'-trihydroxy-flavone, | — | 300 |
| 8 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 9 | Kaempferols | — | 300 |
| 10 | Quercetin | — | 300 |
| 11 | Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is | — | 300 |
| 12 | Lithium Chloride | — | 300 |
| 13 | chrysin | — | 300 |
| 14 | fisetin | — | 78 |
| 15 | ly294002 | — | 11 |
| 16 | egcg | — | 300 |
| 17 | Rutin | — | 300 |
| 18 | Ursolic Acid | — | 300 |
| 19 | Oleanolic Acid | — | 300 |
| 20 | Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione. | — | 300 |
About the APC truncation mutants have impaired AXIN binding Pathway
The APC truncation mutants have impaired AXIN binding pathway is catalogued in Reactome (ID: R-HSA-5467337) and involves 4 genes. In the BiohacksAI corpus, 20 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CSNK1A1, GSK3B, PPP2CA, PPP2R5A.