Defective SLC12A1 causes Bartter syndrome 1 (BS1)
REACTOME PATHWAYThe Defective SLC12A1 causes Bartter syndrome 1 (BS1) pathway (Reactome ID: R-HSA-5619104) involves 1 genes and is affected by 2 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Defective SLC12A1 causes Bartter syndrome 1 (BS1)
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Bumetanide | — | 299 |
| 2 | Furosemide | — | 298 |
About the Defective SLC12A1 causes Bartter syndrome 1 (BS1) Pathway
The Defective SLC12A1 causes Bartter syndrome 1 (BS1) pathway is catalogued in Reactome (ID: R-HSA-5619104) and involves 1 genes. In the BiohacksAI corpus, 2 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include SLC12A1.