Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
REACTOME PATHWAYThe Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) pathway (Reactome ID: R-HSA-5619107) involves 2 genes and is affected by 4 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Aurintricarboxylic Acid | — | 184 |
| 2 | Demeclocycline | — | 297 |
| 3 | Quercetin | — | 300 |
| 4 | Niclosamide | — | 299 |
About the Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) Pathway
The Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) pathway is catalogued in Reactome (ID: R-HSA-5619107) and involves 2 genes. In the BiohacksAI corpus, 4 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GCK, GCKR.