Activation of SMO
REACTOME PATHWAYThe Activation of SMO pathway (Reactome ID: R-HSA-5635838) involves 3 genes and is affected by 15 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Activation of SMO
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Hesperidin | — | 300 |
| 2 | Methylene Blue | — | 200 |
| 3 | Vitamin | — | 295 |
| 4 | Aurintricarboxylic Acid | — | 184 |
| 5 | Cefixime | — | 300 |
| 6 | Flurandrenolone | — | 65 |
| 7 | Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on | — | 299 |
| 8 | streptonigrin | — | 299 |
| 9 | Terbutaline | — | 299 |
| 10 | Tetracycline | — | 300 |
| 11 | aniracetam | — | 110 |
| 12 | Nadolol | — | 297 |
| 13 | Nicardipine | — | 94 |
| 14 | Sorafenib | — | 300 |
| 15 | sp600125 | — | 117 |
About the Activation of SMO Pathway
The Activation of SMO pathway is catalogued in Reactome (ID: R-HSA-5635838) and involves 3 genes. In the BiohacksAI corpus, 15 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ARRB1, CSNK1A1, GRK2.