FRS-mediated FGFR1 signaling
REACTOME PATHWAYThe FRS-mediated FGFR1 signaling pathway (Reactome ID: R-HSA-5654693) involves 3 genes and is affected by 7 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting FRS-mediated FGFR1 signaling
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Sorafenib | — | 300 |
| 2 | Axitinib | — | 298 |
| 3 | alsterpaullone | — | 12 |
| 4 | Dasatinib | — | 299 |
| 5 | sp600125 | — | 117 |
| 6 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 7 | Dactinomycin | — | 297 |
About the FRS-mediated FGFR1 signaling Pathway
The FRS-mediated FGFR1 signaling pathway is catalogued in Reactome (ID: R-HSA-5654693) and involves 3 genes. In the BiohacksAI corpus, 7 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FGF22, FGFR1, GRB2.