SHC-mediated cascade:FGFR3
REACTOME PATHWAYThe SHC-mediated cascade:FGFR3 pathway (Reactome ID: R-HSA-5654704) involves 2 genes and is affected by 6 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting SHC-mediated cascade:FGFR3
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Sorafenib | — | 300 |
| 2 | Axitinib | — | 298 |
| 3 | Crizotinib | — | 298 |
| 4 | Dasatinib | — | 299 |
| 5 | sp600125 | — | 117 |
| 6 | Dactinomycin | — | 297 |
About the SHC-mediated cascade:FGFR3 Pathway
The SHC-mediated cascade:FGFR3 pathway is catalogued in Reactome (ID: R-HSA-5654704) and involves 2 genes. In the BiohacksAI corpus, 6 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FGFR3, GRB2.