Formation of the cornified envelope
REACTOME PATHWAYThe Formation of the cornified envelope pathway (Reactome ID: R-HSA-6809371) involves 4 genes and is affected by 6 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Formation of the cornified envelope
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Rivaroxaban | — | 999 |
| 2 | pentamidine | — | 299 |
| 3 | Diminazene | — | 300 |
| 4 | silver sulfadiazine | — | 299 |
| 5 | Bortezomib | — | 300 |
| 6 | Carbaryl | — | 300 |
About the Formation of the cornified envelope Pathway
The Formation of the cornified envelope pathway is catalogued in Reactome (ID: R-HSA-6809371) and involves 4 genes. In the BiohacksAI corpus, 6 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CAPN1, FURIN, KLK5, ST14.