Reversal of alkylation damage by DNA dioxygenases
REACTOME PATHWAYThe Reversal of alkylation damage by DNA dioxygenases pathway (Reactome ID: R-HSA-73943) involves 2 genes and is affected by 4 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Reversal of alkylation damage by DNA dioxygenases
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Demeclocycline | — | 297 |
| 2 | Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as | — | 300 |
| 3 | tyrphostin ag 1478 | — | 4 |
| 4 | Sulbactam | — | 299 |
About the Reversal of alkylation damage by DNA dioxygenases Pathway
The Reversal of alkylation damage by DNA dioxygenases pathway is catalogued in Reactome (ID: R-HSA-73943) and involves 2 genes. In the BiohacksAI corpus, 4 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ALKBH5, FTO.