Interaction between PHLDA1 and AURKA
REACTOME PATHWAYThe Interaction between PHLDA1 and AURKA pathway (Reactome ID: R-HSA-8854521) involves 1 genes and is affected by 7 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Interaction between PHLDA1 and AURKA
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Sorafenib | — | 300 |
| 2 | Crizotinib | — | 298 |
| 3 | 1-(5,8-dihydro-1,4-dihydroxy-5,8-dioxo-2-naphthyl)-4-methylpent-3-en-1-yl cinnamate [Supplementary Concept] | — | 54 |
| 4 | Axitinib | — | 298 |
| 5 | juglone hydroxylase [Supplementary Concept] catalyzes | — | 279 |
| 6 | kenpaullone | — | 8 |
| 7 | sp600125 | — | 117 |
About the Interaction between PHLDA1 and AURKA Pathway
The Interaction between PHLDA1 and AURKA pathway is catalogued in Reactome (ID: R-HSA-8854521) and involves 1 genes. In the BiohacksAI corpus, 7 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AURKA.