Activated NTRK2 signals through FRS2 and FRS3
REACTOME PATHWAYThe Activated NTRK2 signals through FRS2 and FRS3 pathway (Reactome ID: R-HSA-9028731) involves 2 genes and is affected by 5 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Activated NTRK2 signals through FRS2 and FRS3
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Sorafenib | — | 300 |
| 2 | Crizotinib | — | 298 |
| 3 | tyrosol | — | 300 |
| 4 | sp600125 | — | 117 |
| 5 | Dactinomycin | — | 297 |
About the Activated NTRK2 signals through FRS2 and FRS3 Pathway
The Activated NTRK2 signals through FRS2 and FRS3 pathway is catalogued in Reactome (ID: R-HSA-9028731) and involves 2 genes. In the BiohacksAI corpus, 5 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GRB2, NTRK2.