Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)
REACTOME PATHWAYThe Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) pathway (Reactome ID: R-HSA-9651496) involves 4 genes and is affected by 5 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Gabexate | — | 300 |
| 2 | Rivaroxaban | — | 999 |
| 3 | apixaban [Supplementary Concept] | — | 997 |
| 4 | Bortezomib | — | 300 |
| 5 | Vitamin K 2 | — | 300 |
About the Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) Pathway
The Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) pathway is catalogued in Reactome (ID: R-HSA-9651496) and involves 4 genes. In the BiohacksAI corpus, 5 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include F10, F12, GGCX, KLKB1.